In particular, we focus on the coupling of the elastic constants to the heat capacity. Our most important present interest is the propagation of density pulses in nerves, the role of anesthetics, and the occurrence of ion-channel- like events in pure lipid membranes close to transitions that are due to thermal fluctuations. We established a theory for the action potential that represents them as electromechanical solitons. This approach naturally provides a theory for anesthesia. We perform measurements on nerves in order to establish a generic thermodynamic view of nerve pulses and channels.
We base our work on the theory of fluctuations. This implies that we
do not base our work on the function of single molecules but rather on
the physics of ensembles. Our major aim is to establish a
self-contained view of the
function of biomembranes based on the fluctuation-dissipation theorem
and the coupling of the susceptibilities.
Popular review Physik Journal 3/2009 (in German)
english translation, 2010 (arXiv)
|Review on nerves and anesthesia 2007
Review on nerves and anesthesia 2009
Review on lipid ion channels 2010
Thermal Biophysics of Membranes, 2007
Monographie, 330 pages, Hardcover