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Biophysics of Nerves : 24.10.2013

Graduate Course. Block 2, 2013 / 2014, Skema A

schedule: Tuesdays 8-12, Thursdays 9-12, place: Aud. B, Blegdamsvej 17
place: Aud. B, Blegdamsvej 17
first class: Tuesday, Nov. 19, 2013, time: 8:15
exam: Thursday Jan. 23, 2014, Aud. B, Blegdamsvej 17 (reexam: Thursday, Apr. 10, 2014)

Link to KU kurser page Link to Time and Place --> current handout and other material

ABSTRACT:

This course introduces into the foundations of the biophysics of nerve pulses and synaptic transmission. This includes the treatment of the basic physical features of nerves, electrical conductance through cell membranes, cable theory, ion channels and in particlular the Hodgkin-Huxley model, which forms the basis of the accepted models for the action potential. Synaptic transmission will include electrical postsynaptic phenomena, long term potentiation and Hepp-synapses. We contrast this classical theory of nerves by a fundamental thermodynamical treatment of nerves leading to the possibility of solitons in membranes, thus forming an alternative basis for the origin of the nervous pulse.

For physicists, chemists, biochemists and related subject after the bachelor.
LITERATURE:
There will be handouts that are sufficient for understanding. The following is recommended reading.
- D. Johnston and S. M. S. Wu, Cellular Neurophysiology, MIT Press, 1995
- B. Hille,Ionic Channels of Excitable Membranes, Sinauer Associates, Sunderland, 1992
- R. D. Keynes & D. J. Aidley, Nerve & Muscle, Cambridge University Press 1991

- Selected publications


contact: T. Heimburg, NBI, Blegdamsvej 17, Kc9 - Tel: 3532 5389. E-mail: theimbu@nbi.dk